Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents.
نویسندگان
چکیده
The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides their antitumor, analgesic and anti-inflammatory activities. The results showed that the ratios of brucine to strychnine were 1:2.05 and 2.2:1 for TAF and MTAF, respectively, and the toxicity of TAF was about 3.17-fold higher than that of MTAF. Compared to brucine alone, the elimination of brucine was found to be inhibited by other alkaloids in TAF or MTAF except strychnine. Significantly increased pharmacological activities when administered by the oral route were obtained with MTAF in comparison to TAF and nux vomica powder (NVP). In summary, MTAF might replace NVP and TAF in the clinical application of Chinese medicine to obtain much higher efficacy.
منابع مشابه
A rare case of strychnine poisoning by consumption of Strychnos nux- vomica leaves
Strychnine is one of the oldest poisons known to man. The source of this potent toxin is the Strychnos nux-vomica plant, which actually contains two distinct alkaloidsstrychnine and brucine. Although principally found in the seeds, these alkaloids can be isolated in varying concentrations from virtually all parts of the plant including the bark, leaves and roots[1]. Once consumed, strychnine pr...
متن کاملStrychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
BACKGROUND Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE The present study was aime...
متن کاملEffect of purificatory measures through cow's urine and milk on strychnine and brucine content of Kupeelu (Strychnos nuxvomica Linn.) seeds.
Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial. Ayurveda advocates that nux vomica seeds are to be administered in therapeutics only after going through certain purificatory measures (Shodhana). There are more than six media: cow's urine (Go mutra), cow's milk...
متن کاملA short review on anticancer investigations of Strychnos nux-vomica
Herbs used in traditional medicine have provided a nidus for the discovery of various new molecules having therapeutic viability. With the advent of various diseases, the science has also armed itself to combat the everevolving family of diseases with the help of these new molecules. Cancer is one such area which has limited scope for management through conventional therapy. Recent research adv...
متن کاملThe apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway.
In an attempt to dissect the mechanism of Strychnos nux-vomica, a commonly used Chinese folk medicine in the therapy of liver cancer, the cytotoxic effects of four alkaloids in Strychnos nux-vomica, brucine, brucine N-oxide, strychnine, and isostrychnine, on human hepatoma cells (HepG2) were screened by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrasolium bromide (MTT) assay. Brucine, among th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecules
دوره 19 4 شماره
صفحات -
تاریخ انتشار 2014